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KMID : 0613820060160020310
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Journal of Life Science
2006 Volume.16 No. 2 p.310 ~ p.314
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Antifungal Activity of Fistulosides, Steroidal Saponins, from Allium fistulosum L.
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Sohn Ho-Yong
Kum Eun-Joo
Ryu Hee-Young
Jeon Su-Jin
Kim Nam-Soon
Son Kun-Ho
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Abstract
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Allium fistulosum L. (Welsh onion) is a perennial herb that is widely cultivated throughout the world, especially in China, Japan and Korea. Although, various activities were reported, little is known about antimicrobial activity of A. fistulosum L.. In this study, strong antimicrobial substances, fistuloside A, B, and C were isolated from the edible parts of A. fistulosum L. and their antimicrobial activity was evaluated with pathogenic- or food-spoilage microorganism based on disk-diffusion assay, minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) determination. Fistuloside A and fistuloside C showed strong antifungal activity and anti-Proteus activity, while fistuloside B is effective to only fungi. The fistuloside C showed a prominent antifungal activity with 3.1~6.2 ㎍/㎖ of MIC and MFC. Our results indicated that fistuloside C has a prominent antifungal activity and support the use of A. fistulosum to treat microbial infection.
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KEYWORD
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Allium fistulosum L., antifungal activity, fistuloside, fungicidal activity, steroidal sapon
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